姓名

李颜

研究方向：

免疫学/

人源化小鼠模型

联系方式

[email protected]

学术兼职：

国际人源化小鼠大会(IWHM)科学委员会成员

中国细胞生物学会免疫细胞分会委员

中国医药生物技术协会-疾病模型分会委员

中国抗癌协会肿瘤免疫代谢分会委员

江苏省细胞与发育生物学学会理事

Frontiers in Immunology人源化小鼠专刊副主编

个人简介

李颜博士，海角社区 教授/医药生物技术国家重点实验室研究员, 国家重点研发计划青年项目首席（原青年973首席），国自然基金委优青，江苏省“双创团队领军人才”，“省特聘教授”。研究关注小鼠模型与人体的物种差异，为加速基础生物学发现向临床疾病治疗的转化，本课题组研发了一系列小鼠品系和实验方法，将人免疫系统与多种人体组织嵌合到小鼠中，解决传统小鼠模型与临床试验难以回答的科学问题。当前课题组方向包括：（1）新型免疫人源化小鼠模型；（2）人体器官+免疫双人源化小鼠模型；（3）肿瘤及自身免疫系统疾病的免疫治疗；（4）人体免疫细胞发育及功能。其研究成果发表在Cell，Nature Methods，Nature Communications，Science Advances等期刊，申报获得多项国内专利，以及一项国际专利并转化。

代表性论文[近5年通讯作者和第一作者]

1. Deshan Ren, Wei Liu, Shuai Ding, Yan Li*(2022) The creation of human immune system mice and hydrodynamic injection to modulate human hematopoiesis in vivo, STAR protocols

2. Xiufei Chen, Wenjie Zhou, Ren-Hua Song, Shuang Liu, Shu Wang, Yujia Chen, Chao Gao, Chenxi He, Jianxiong Xiao, Lei Zhang, Tianxiang Wang, Peng Liu, Kunlong Duan, Chen Zhang, Jinye Zhang, Yiping Sun, Felix Jackson, Fei Lan, Yun Liu, Yanhui Xu, Justin Jong-Leong Wong, Pu Wang, Hui Yang, Yue Xiong, Tong Chen*, Yan Li*, Dan Ye*.(2022) Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity, Science Advances

3. Tao Cheng, Shuai Ding, Shanshan Liu, Yan Li*, Lingyun Sun* (2021).Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis. Theranostics

4. Wei Liu; Hua Song; Xiaojing Li; Deshan Ren; Shuai Ding; Yan Li* (2021). Lipid Metabolism in Tumor Associated Myeloid-Derived Suppressor Cells, Lipid Metabolism in Tumor Immunity, Springer Book 

5. Shuai Ding, Siqi Li, Shujie Zhang and Yan Li * (2020) Genetic alterations and checkpoint expression: mechanisms and models for drug discovery. Regulation of Cancer Immune Checkpoints，Springer Book

6. Yan Li, Guillemette Masse Ranson, Zacarias Garcia, Timothee Bruel, Ayrin Kok-Harunova, Helene Strick-Marchand, Gregory Jouvion, Nicolas Serafini, Ai Ing Lim, Mathilde Dusseaux, Thierry Hieu, Frank Bourgade, Antoine Toubert, Daniela Finke, Oliver Schwartz, Phillippe Bousso, Hugo Mouquet and James P. Di Santo. (2018) A human immune system mouse model with robust lymph node development. Nature Methods 

7. Yan Li, Helene Strick-Marchand, Ai Ing Lim, Jiazi Ren, Guillemette Masse-Ranson, Dan Li, Gregory Jouvion, Lars Rogge, Sophie Lucas, Bin Li and James P. Di Santo. (2017) Regulatory T cells control toxicity in a humanized model of IL-2 therapy. Nature Communications 

8. Ai Ing Lim, Yan Li, Silvia Lopez-Lastra, Ralph Stadhouders, Franziska Paul, Armanda Cassrouge, Nicolas Serafini, Anne Puel, Laura Surace, Guillemette Masse-Ranson, Helene Strick-Marchand, Lionel Le Bourhis, Roberto Cocchi, Davide Topazio, Paolo Graziano, Lucia Anna Muscarella, Lars Rogge, Jean-Michel Sallenave, Matthieu Allez, Thomas Graf, Rudi W. Hendriks, Jean-Laurent Casanova, Ido Amit, Hans Yssel and James P. Di Santo. (2017) Systemic human ILC precursors provide a substrate for tissue ILC differentiation, Cell

承担科研项目[项目负责人]

获奖情况

l Travel Award, 5^th International workshop on humanized mice, Switzerland

l Outstanding Young Investigator, 4^th International workshop on humanized mice, Korea